CBDV, a big shift in CBD

CBDV research hints this rare non-psychoactive cannabinoid can be a big game changer to the medical field, as it is showing dramatic benefits to the symptoms of incurable conditions such as autism and Rhett’s syndrome. Furthermore, CBDV appears to be a great staple to add to your regular health and wellness routine, as research shows it to be a potent antioxidant. Here we’ll talk about what it is and what it can do for you.


Cannabidivarin, shortly termed CBDV, is a chemical compound produced from cannabis with almost the same molecular structure as CBD. It is one of over 100 cannabinoids described from the cannabis plant that interacts with the body’s endocannabinoid system to produce a set of effects. These said effects have nothing to do with the senses, though. They are more therapeutic.


CBDV research is still in its early stages. However, researchers have confirmed that it seems to be offering therapeutic effects on certain disorders that are not treatable. We’ve only got a grasp of CBDV’s possible medical uses, but it’s clear that the compound has a lot of promise. All CBD-related cannabinoids like CBDA and CBDV seem to share properties and benefits in the body, including:

lessening seizures
reducing inflammations
treating chronic pain
alleviating nausea
regulating mood


Until recently, most research was preclinical, meaning the studies focused on mice instead of people. But in the last few years, clinical studies on disorders that have been hard to treat in the past have shown great results. Here are some examples of conditions for which CBDV is especially good at relieving symptoms:

  • Seizure and Nausea – Similar to CBD, CBDV significantly reduces the frequency and severity of seizures. It also lessens or completely eliminates nausea associated with various ailments and can help reduce inflammation in the body.

  • Antioxidant – Improves the body’s natural cleaning process of unwanted debris, such as damaged cells, to regenerate newer, healthier cells. Because of this, CBDV is also a frontier compound when it comes to treating Multiple Sclerosis.

  • Muscular dystrophy – An Italian study found that CBD and CBDV (1), but not THCV, could improve autophagy, restore the function of muscle stem cells, and reduce inflammation. To get these results, you had to take high doses of CBD or CBDV. CBD and CBDV may even be able to treat the underlying pathophysiology of more than just DMD.

  • Autism – A new study (2) found that CBDV relieves symptoms such as seizures, chronic anxiety, addictive behavior, and mood disorders in Autism Spectrum Disorder (ASD).

  • Rhett’s Syndrome – Research (3) on CBDV shows that it improves motor coordination and social deficits and normalizes brain weight in Rhett’s Syndrome patients.

  • Gut inflammatory conditions – In 2019 research (4), CBDV has been shown to have enhanced anti-inflammatory effects on the gastrointestinal tract. This seems to be a hopeful treatment for many guts or digestive problems like Crohn’s disease and IBD.


Despite sharing many things in common, researchers found what sets CBDV apart from CBD. While CBD is well-known for its therapeutic properties for people in recovery. CBDV, on the other hand, has come under the microscope for its high potential in treating neurological imbalances.

It not only stops seizures like CBD but also lowers the frequency and severity of seizures in people with Intractable Epilepsy. CBDV also does a lot more in regulating mood than CBD, with evidence showing its remarkable effects in treating mood disorders.


As the cannabinoids’ lookout list keeps growing, deciding which is good for you depends entirely on the purpose you are using it for. CBDV is being studied on its own and for conditions that CBD isn’t being studied for.

CBD regulates the endocannabinoid system by blocking pain, inhibiting inflammation, and promoting a relaxed mental state. CBDV is being researched for its potential use in treating certain neurological or mood disorders. And CBDV has been under the radar recently because CBD has been shown to lose its effectiveness as an antiepileptic drug over time.


CBDV was first found in 1969. It changed the way scientists thought about cannabinoids at the time. Before, it was thought that all naturally occurring cannabinoid compounds had a pentyl side chain, consisting of five carbons.

To be clear, slight changes in the molecular structure of cannabinoids can also shift the cannabinoids’ properties.

The distinction between CBD and CBDV is in their molecular level.

When CBDV is processed, it will cause changes on the atomic level, precisely the number of carbon atoms in one of the side chains. CBD contains a pentyl group, which means it has five carbons in its chain. CBDV has three carbons because it has a propyl group.

Soon after finding and isolating CBDV, scientists also isolated tetrahydrocannabivarin (THCV), the propyl cannabinoid version of tetrahydrocannabinol, the main psychoactive ingredient in cannabis (THC).


You can use CBDV in the same ways you have been using CBD and THC for consumption. CBDV can be added to oils, tinctures, and edibles, or you can smoke flower strains with higher levels of CBD. It can also be blended into vape cartridges via oils and extracts.


CBDV is a cannabinoid you cannot typically find in dispensaries and CBD shops. It is naturally produced in cannabis, but only in tiny amounts. Though common strains, like Harlequin and Sweet Island, contain CBDV, it is not usually disclosed because it is still understudied.

CBDV is seen highly in “landrace” strains. Landraces are strains native to some parts of the world. Mexican, Asian and African landrace cannabis strains are reported to have higher levels of both CBDV and THCV and low concentrations of THC. Cannabis cultivators began using these plants to breed new strains of CBDV and THCV that are stronger and have more potency. Some of the most CBDV-rich strains available are:

Forbidden V
Pine Walker
Medical Mass
Painkiller XL
Royal Medic
Dance World


No, it cannot get you high. However, the idea that it is not psychotropic is not the whole picture. It may affect your conscious experience. People who have used it said they felt more relaxed, in less pain, and albeit just consciously too comfortable.


As cannabis and hemp-based products are becoming more acceptable to the populace, scientists are studying them further, especially the not-so-common cannabinoids like CBDV, hoping to treat serious conditions. CBDV was discovered some time ago, but research on this compound was given too little attention because of the supposed cannabis’s past negative image.

Given all of the facts stated, we can conclude that:
CBDV is a naturally occurring compound found in hemp plants, and it has healing properties and can be helpful as a medical treatment. There will be more extensive studies queued for CBDV and new strains will be created or developed for easier availability for everybody.

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1 Iannotti FA, Pagano E, Moriello AS, Alvino FG, Sorrentino NC, D’Orsi L, Gazzerro E, Capasso R, De Leonibus E, De Petrocellis L, Di Marzo V. (2019 May, Epub 2018 September 9). Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice. National Library of Medicine. https://pubmed.ncbi.nlm.nih.gov/30074247/

2 Enriquez. Keri. (2019, September 29). Can marijuana help treat autism symptoms? A new study aims to find out. CNN Health. https://edition.cnn.com/2019/09/29/health/cannabis-autism-weed-5/index.html

3 Daniele Vigli, Livia Cosentino, Carla Raggi, Giovanni Laviola, Marie Woolley-Roberts, Bianca De Filippis. (2018, September 15). Chronic treatment with the phytocannabinoid Cannabidivarin (CBDV) rescues behavioural alterations and brain atrophy in a mouse model of Rett syndrome. Neuropharmacology, ScienceDirect.

4 Pagano E, Romano B, Iannotti FA, Parisi OA, D’Armiento M, Pignatiello S, Coretti L, Lucafò M, Venneri T, Stocco G, Lembo F, Orlando P, Capasso R, Di Marzo V, Izzo AA, Borrelli F. (2019 November). The non-euphoric phytocannabinoid cannabidivarin counteracts intestinal inflammation in mice and cytokine expression in biopsies from UC pediatric patients. National Library of Medicine. https://pubmed.ncbi.nlm.nih.gov/31553934/

Erica Zamberletti, Tiziana Rubino, Daniela Parolaro. (2021 October). Therapeutic potential of cannabidivarin for epilepsy and autism spectrum disorder. Pharmacology & Therapeutics, ScienceDirect.

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